Comparison of 50 μg and 25 μg doses of intrathecal morphine on postoperative analgesic requirements in patients undergoing transurethral resection of the prostate with intrathecal anesthesia

Duman A., Apiliogullari S., Balasar M., Gürbüz R., Karcioglu M.

Journal of Clinical Anesthesia, vol.22, no.5, pp.329-333, 2010 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 5
  • Publication Date: 2010
  • Doi Number: 10.1016/j.jclinane.2009.09.006
  • Journal Name: Journal of Clinical Anesthesia
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.329-333
  • Keywords: Intrathecal morphine, Postoperative analgesia, Transurethral resection of prostate
  • Hatay Mustafa Kemal University Affiliated: Yes

Abstract

Study Objective: To compare the efficacy of 50 μg and 25 μg doses of intrathecal morphine on postoperative pain in patients undergoing transurethral resection of the prostate (TURP) with low-dose bupivacaine. Design: Randomized, double-blinded study. Setting: Konya Hospital. Patients: 70 ASA physical status I, II, and III patients. Interventions: Patients were randomized to two groups: Group A patients received 5 mg of 0.5% hyperbaric bupivacaine (one mL) and 50 μg of morphine (0.5 mL). Group B patients received 5 mg of 0.5% hyperbaric bupivacaine (one mL) and 25 μg of morphine (0.5 mL). Measurements: Postoperative pain scores, patient and surgeon satisfaction, and side effects such as emesis, pruritus, and respiratory depression, were recorded. Main Results: Postoperative pain characteristics were similar between the two groups. Frequency of emesis was similar between the groups, while pruritus was significantly higher in Group A. No antipruritic medication was required in any patient. Patient and surgeon satisfaction was evaluated as good or excellent in both groups. Conclusions: Intrathecal morphine at a dose of 25 μg provides similar postoperative analgesia and less pruritus than the 50 μg dose in patients undergoing TURP. © 2010 Elsevier Inc. All rights reserved.