Enantioselective Addition of Diethylzinc to Aromatic Aldehydes Using Chiral Oxazoline-Based Ligands
Russian Journal of Organic Chemistry, vol.56, no.7, pp.1304-1312, 2020 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 56 Issue: 7
- Publication Date: 2020
- Doi Number: 10.1134/s1070428020070271
- Journal Name: Russian Journal of Organic Chemistry
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
- Page Numbers: pp.1304-1312
- Keywords: 1,2-addition, asymmetric catalysis, chiral oxazoline-based ligands, enantioselective synthesis
- Hatay Mustafa Kemal University Affiliated: No
Abstract
Abstract: Chiral oxazoline ligands containing an aromatic ring were prepared fromnorephedrine and pyrrole-2-carbonitrile or 2-hydroxybenzoyl chloride. Thesynthesized ligands were used in the copper-catalyzed asymmetric addition ofdiethylzinc to aromatic aldehydes to provide optically active 1-arylpropan-1-olswith high conversion (92%) and enantioselectivity (up to 99% ee).