Enantioselective Addition of Diethylzinc to Aromatic Aldehydes Using Chiral Oxazoline-Based Ligands

Aydin A. E.

Russian Journal of Organic Chemistry, cilt.56, sa.7, ss.1304-1312, 2020 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Sayı: 7
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1134/s1070428020070271
  • Dergi Adı: Russian Journal of Organic Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
  • Sayfa Sayıları: ss.1304-1312
  • Anahtar Kelimeler: 1,2-addition, asymmetric catalysis, chiral oxazoline-based ligands, enantioselective synthesis
  • Hatay Mustafa Kemal Üniversitesi Adresli: Hayır

Özet

Abstract: Chiral oxazoline ligands containing an aromatic ring were prepared fromnorephedrine and pyrrole-2-carbonitrile or 2-hydroxybenzoyl chloride. Thesynthesized ligands were used in the copper-catalyzed asymmetric addition ofdiethylzinc to aromatic aldehydes to provide optically active 1-arylpropan-1-olswith high conversion (92%) and enantioselectivity (up to 99% ee).