Enantioselective Addition of Diethylzinc to Aromatic Aldehydes Using Chiral Oxazoline-Based Ligands
Russian Journal of Organic Chemistry, cilt.56, sa.7, ss.1304-1312, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 56 Sayı: 7
- Basım Tarihi: 2020
- Doi Numarası: 10.1134/s1070428020070271
- Dergi Adı: Russian Journal of Organic Chemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier
- Sayfa Sayıları: ss.1304-1312
- Anahtar Kelimeler: 1,2-addition, asymmetric catalysis, chiral oxazoline-based ligands, enantioselective synthesis
- Hatay Mustafa Kemal Üniversitesi Adresli: Hayır
Özet
Abstract: Chiral oxazoline ligands containing an aromatic ring were prepared fromnorephedrine and pyrrole-2-carbonitrile or 2-hydroxybenzoyl chloride. Thesynthesized ligands were used in the copper-catalyzed asymmetric addition ofdiethylzinc to aromatic aldehydes to provide optically active 1-arylpropan-1-olswith high conversion (92%) and enantioselectivity (up to 99% ee).