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Yüzüncü Yıl Üniversitesi Veteriner Fakültesi Dergisi, vol.19, no.1, pp.29-33, 2008 (Peer-Reviewed Journal)
The objective of this study was to determine the effects of different induction agents on the antioxidative activity of desflurane in dogs. Sixteen healthy male crossbreed dogs, aged between 1 and 2 years and weighing between 16 and 22 kg were equally divided into two groups. Anaesthetic protocols were designed as midazolam + thiopental + desflurane (Thio-Des group) or midazolam + ketamine + desflurane (Ket-Des group). Anaesthesia was induced with 0.3 mg kg-1 midazolam + 10 mg kg-1 thiopental or 0.3 mg kg-1 midazolam + 10 mg kg-1 ketamine hydrochloride combinations intraveneously. Anaesthesia maintenance was continued for 70 min(s) with 7-8% desflurane. Blood catalase, superoxide dismutase and hemoglobin activities were measured at control, anaesthesia induction, during the desflurane anaesthesia, one hour after anaesthesia and 24 hours after anaesthesia. In conclusion, thiopental administration in the anaesthesia induction increased superoxide dismutase activity (p<0.05), whereas ketamine administration increased the catalase (p<0.05) and hemoglobin (p<0.01) activities during desflurane anaesthesia. But, these enzymes simultaneously decreased in both groups one day after anaesthesia (p>0.05). Therefore, it is possible that induction agents play a significant rol on the antioxidative effects of desflurane anaesthesia.