Antimicrobial Activity of Some Thiourea Derivatives and Their Nickel and Copper Complexes

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Arslan H., DURAN N., Borekci G., Ozer C. K., Akbay C.

MOLECULES, no.1, pp.519-527, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2009
  • Doi Number: 10.3390/molecules14010519
  • Journal Name: MOLECULES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.519-527
  • Keywords: Antibacterial activity, Antifungal activity, Complexes, In vitro studies, Lipophilicity, Thiourea derivatives
  • Hatay Mustafa Kemal University Affiliated: Yes

Abstract

Five thiourea derivative ligands and their Ni2+ and Cu2+ complexes have been synthesized. The compounds were screened for their in vitro anti-bacterial activity using Gram-positive bacteria (two different standard strains of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Streptococcus pyogenes, Bacillus cereus) and Gram-negative bacteria (Esherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Proteus vulgaris, Enterobacter aerogenes) and in vitro anti-yeast activity (Candida albicans, Candida krusei, Candida glabrata, Candida tropicalis, Candida parapsilosis). The minimum inhibitory concentration was determined for all ligands and their complexes. In vitro anti-yeast activity of both ligands and their metal complexes is greater than their in vitro anti-bacterial activity. The effect of the structure of the investigated compounds on the antimicrobial activity is discussed.