Radioprotective effect of montelukast sodium against hepatic radioiodine (<SUP>131</SUP>I) toxicity: A histopathological investigation in the rat model
ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI, cilt.62, sa.1, ss.37-43, 2015 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 62 Sayı: 1
- Basım Tarihi: 2015
- Doi Numarası: 10.1501/vetfak_0000002655
- Dergi Adı: ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.37-43
- Hatay Mustafa Kemal Üniversitesi Adresli: Hayır
Özet
Radioactive iodine (I-131) is a known radionuclide which is used both for diagnostic and therapeutic purposes in the treatment of hyperthyroidism and thyroid cancer. Montelukast sodium (Cysteinyl leukotriene receptor-1 antagonist) is also a well-known antioxidant drug. This study aimed to evaluate the histopathological changes in rat livers at the third month following I-131 treatment and the radioprotective effect of Montelukast sodium (ML) against I-131-related liver damage. Thirty female Wistar Albino rats were randomly divided into three groups as control group (n=10), untreated rats; second (RAI) group (n=10), oral radioiodine (111 MBq) administrated rats, and third (ML) group (n=10), oral radioiodine and ML administrated rats. In the third group, ML administration was started"3 days before and ended 10 days after RAI administration. In the third month of radioiodine (RAI) administration, the animals were decapitated and the livers were removed for histopathological examination. The histopathologic data were evaluated comparatively by using Mann Whitney U and Fisher's Exact Tests Differences were determined in all the parameters in terms of intensity between the control and I-131 groups, which showed the harmful effects of I-131. In the comparison of the I-131 and ML groups, hyperemia was determined respectively 80% to 40%, the presence of inflammatory cells 70% to 60% and capsule thickening 70% to 40%. Montelukast sodium was observed to have a protective effect especially on hyperemia and capsule thickening. According to the study results, radioactive iodine (I-131) treatment seems to cause morphological damage to the rat liver, and Montelukast sodium effectively protects the liver against damage.