Biomechanic and biochemical analysis of the effects of local Ankaferd Blood Stopper® application on osseointegration of titanium implants
International Dental Research, vol.12, no.1, pp.27-33, 2022 (TRDizin)
- Publication Type: Article / Article
- Volume: 12 Issue: 1
- Publication Date: 2022
- Doi Number: 10.5577/intdentres.2022.vol12.no1.5
- Journal Name: International Dental Research
- Journal Indexes: TR DİZİN (ULAKBİM)
- Page Numbers: pp.27-33
- Open Archive Collection: AVESIS Open Access Collection
- Hatay Mustafa Kemal University Affiliated: Yes
Abstract
Aim: Investigations into Ankaferd Blood Stopper® (ABS) on bone healing have revealed positive bone regeneration effects. The exact mechanism of this positive bone tissue metabolism effect is unknown. This study’s aim is a biomechanic and biochemical investigation of the effects of local ABS application on the osseointegration of titanium implants. Methodology: Sprague Dawley rats were divided into four groups of ten rats each. The control group (n=20) received no treatment during the experimental period, while the ABS group (n=20) had ABS applied locally during the surgical application of the titanium implant before insertion into the bone sockets. After 2 (controls n=10 and ABS n=10) and 4 weeks (controls n=10 and ABS n=10) experimental periods, the rats were sacrificed and implants with surrounding bone tissues were removed for reverse torque analysis (Newton), blood sample collection, and biochemical analysis. Results: The biomechanic bone implant contact ratio detected was higher in week 4 than in week 2 in the ABS group (p<0, 05). Lower phosphor levels were detected in the ABS group than in the 4-week controls (p<0, 05). Conclusion: According to the biomechanical parameters, ABS is more effective after four weeks than after two weeks when locally applied.