Effects of the bovine aniniotic membrane on comeal healing with acute alkali burns hi rabbits

Gonenci R., ALTUĞ M. E., Koc A., Oksuz H., Yuksel H.

Journal of Animal and Veterinary Advances, vol.8, no.8, pp.1653-1659, 2009 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 8
  • Publication Date: 2009
  • Journal Name: Journal of Animal and Veterinary Advances
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1653-1659
  • Keywords: Alkali burn, BAM, Bovine amniotic membrane, Cornea, Rabbit, Transplantation
  • Hatay Mustafa Kemal University Affiliated: Yes

Abstract

The Bovine Ammotic Membrane (BAM) was transplanted on the right cornea of 8 adult rabbits after an alkali burn was created with 2.5 N NaOH. Density and area of the corneal opacity, area of the corneal epithelial defect, vascularization and complications were clinically evaluated. Left corneas of the same animals were used as active control group. At the end of the experiment, all the eyes were extirpated and histologically examined on light microscopy. BAM has decreased density and area of the corneal opacity and increased reepithelialisation, but promoted episcleral vasodilatation more prominently in clinical examination. Histologically; the distrubition of Polymorphonuclear (PMN) leucocytes, corneal thicknesses, edema, keratinization, neovascularization and inflammation were significantly reduced by BAM compared to active control group. BAM was highly found to be effective to restore the corneal surface with acute alkali burns in the rabbit. © Medwell Journals, 2009.