Enantioselective Aldol Reaction between Isatins and Ketones, Catalyzed by Chiral Norephedrine-Derived β-Amino Alcohols with a Thiophene Moiety

AYDIN A. E.

Russian Journal of Organic Chemistry, vol.58, no.6, pp.820-829, 2022 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 58 Issue: 6
  • Publication Date: 2022
  • Doi Number: 10.1134/s1070428022060100
  • Journal Name: Russian Journal of Organic Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core
  • Page Numbers: pp.820-829
  • Keywords: aldol reaction, chiral amino alcohols, enantioselective reaction, isatin
  • Hatay Mustafa Kemal University Affiliated: Yes

Abstract

Abstract: Chiral norephedrine-based β-amino alcohol bearing a substituted thiophene ring were applied as catalysts for the enantioselective aldol reaction of isatins with ketones. Using enantiomeric chiral amino alco­hols, the desired aldol products were obtained in high yields and excellent enantioselectivities (up to 95% ee) under optimized conditions.