Enantioselective Aldol Reaction between Isatins and Ketones, Catalyzed by Chiral Norephedrine-Derived β-Amino Alcohols with a Thiophene Moiety

AYDIN A. E.

Russian Journal of Organic Chemistry, cilt.58, sa.6, ss.820-829, 2022 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 6
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1134/s1070428022060100
  • Dergi Adı: Russian Journal of Organic Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core
  • Sayfa Sayıları: ss.820-829
  • Anahtar Kelimeler: aldol reaction, chiral amino alcohols, enantioselective reaction, isatin
  • Hatay Mustafa Kemal Üniversitesi Adresli: Evet

Özet

Abstract: Chiral norephedrine-based β-amino alcohol bearing a substituted thiophene ring were applied as catalysts for the enantioselective aldol reaction of isatins with ketones. Using enantiomeric chiral amino alco­hols, the desired aldol products were obtained in high yields and excellent enantioselectivities (up to 95% ee) under optimized conditions.