The Complete Success in Refractory Mooren’s Ulcer Treated with Infliximab
Ocular Immunology and Inflammation, vol.31, no.4, pp.682-688, 2023 (SCI-Expanded, Scopus)
- Publication Type: Article / Letter
- Volume: 31 Issue: 4
- Publication Date: 2023
- Doi Number: 10.1080/09273948.2022.2091615
- Journal Name: Ocular Immunology and Inflammation
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, MEDLINE, Veterinary Science Database
- Page Numbers: pp.682-688
- Keywords: Anti-tumor necrosis factor alpha, immunosuppresion, infliximab, Mooren’s ulcer, peripheral ulcerative keratitits
- Hatay Mustafa Kemal University Affiliated: Yes
Abstract
Purpose: To describe the management and outcome of two extremely rare and painful cases of Mooren’s ulcer, an idiopathic peripheral autoimmune-associated ulcerative corneal disease. Methods: Case report with literature review on the management of ocular inflammation in Mooren’s ulcer. Results: A 47-year-old female and a 76-year-old female presented with progressive bilateral Mooren’s ulcer that were refractory to conventional immunosuppressive therapy. Following treatment with infliximab, an anti-tumor necrosis factor alpha, a significant improvement in disease progression was observed, with no corneal thinning or perforation at follow-ups. Conclusion: This case report highlights how infliximab can be effective in cases with Mooren’s ulcer refractory to conventional therapies.