Serum endothelial leukocyte adhesion molecule-1 and intercellular Adhesion molecule-1 levels in rheumatoid artritis

Canataroglu A., Erken E., GÜNEŞAÇAR R.

Annals of Medical Sciences, cilt.9, sa.2, ss.43-47, 2000 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 2
  • Basım Tarihi: 2000
  • Dergi Adı: Annals of Medical Sciences
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.43-47
  • Anahtar Kelimeler: Adhesion molecules, Endothelial leukocyte adhesion molecule-1 (ELAM-1), Intercellular adhesion molecule-1 (ICAM-1), Rheumatoid arthritis
  • Hatay Mustafa Kemal Üniversitesi Adresli: Evet

Özet

Purpose: To investigate the serum levels of adhesion molecules, soluble endothelial adhesion molecule-1 (sELAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1), in active and inactive patients with rheumatoid arthritis (RA) and to find out their importance as a parameter in the active phase of the disease. Methods: sELAM-1 and sICAM-1 levels were measured in 30 active and 23 inactive RA patients, in 21 Behcet's disease (BD) patients and in 23 healthy subjects by using enzyme immunoassay (ELISA). Results: sELAM-1 levels of active RA patients were found to be increased than those of BD patients and healthy controls (p < 0.05). sICAM-1 levels of active and inactive RA patients were higher than those of healthy subjects (p < 0.05 for both), but no differences were observed when compared to BD patients (p > 0.05 for both). No differences were observed in the levels of sELAM-1 and sICAM-1 between active and inactive RA patients. There was a correlation between sELAM-1 and sICAM-1 levels in active RA patients and in healthy controls. Conclusion: It can be concluded that ELAM-1 and ICAM-1 may play roles in the pathogenesis of RA but cannot be used as disease activity parameters.