The correlation between lymphocyte/monocyte ratio and coronary collateral circulation in stable coronary artery disease patients

Kurtul A., Duran M.

Biomarkers in Medicine, vol.11, no.1, pp.43-52, 2017 (SCI-Expanded, Scopus) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 1
  • Publication Date: 2017
  • Doi Number: 10.2217/bmm-2016-0179
  • Journal Name: Biomarkers in Medicine
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.43-52
  • Keywords: coronary atherosclerosis, coronary collateral circulation, inflammation, lymphocyte, lymphocyte/monocyte ratio, monocyte, stable coronary artery disease
  • Hatay Mustafa Kemal University Affiliated: No

Abstract

Aim: Coronary collateral circulation (CCC) has an important impact on cardiovascular prognosis and well-developed CCC is associated with better clinical outcomes. We investigated whether lymphocyte/monocyte ratio (LMR) has an association with CCC in patients with stable coronary artery disease (SCAD). Methods: The study population consisted of 245 patients with SCAD. Patients were classified into a poor CCC group (Rentrop grades 0/1, n = 87), or good CCC group (Rentrop grades 2/3, n = 158). Results: LMR values were significantly higher in patients with good CCC than in those with poor CCC (4.41 ± 1.58 vs 2.76 ± 1.10; p < 0.001). In receiver operating characteristic analysis, optimal cutoff of LMR for predicting well-developed CCC was 3.38. In multivariate analysis, LMR >3.38 (OR 4.637; p = 0.004), high sensitivity C-reactive protein (OR 0.810, p < 0.001), dyslipidemia (OR 2.485; p = 0.039), and presence of chronic total occlusion (OR 16.836; p < 0.001) were independent predictors of well-developed CCC. Conclusion: Increased LMR predicts well-developed CCC in SCAD patients.