Clinical, pathological and immunohistochemical findings of bovine cutaneous papillomatosis Sıgırlarda deri papillomunda klinik, patolojik ve immunohistokimyasal bulgular

Özsoy Ş. Y., Özyildiz Z., Güzel M.

Ankara Universitesi Veteriner Fakultesi Dergisi, cilt.58, sa.3, ss.161-165, 2011 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 3
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1501/vetfak_0000002468
  • Dergi Adı: Ankara Universitesi Veteriner Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.161-165
  • Anahtar Kelimeler: Bovine papillomatosis, BPV-1, KI-67, PCNA
  • Hatay Mustafa Kemal Üniversitesi Adresli: Evet

Özet

Bovine cutaneous papillomatosis caused by a bovine papillomavirus, is a common skin disease in Turkey. The aim of the present study was to describe the clinical, histopathological and immunohistochemical aspects of naturally occurring bovine cutaneous papillomatosis. A total of 82 Holstein cattle (9.5%), aged between 5 and 24 months, were diagnosed as cutaneous papilloma by clinical examination. The percentage of papilloma and papillomatosis in male and female was found in 7.3% and 14.8%, respectively. The cauliflower-like growths of varying sizes (0.5-11 cm) were mostly located on the head (63.2%). Histopathology revealed various degrees of acanthosis and hyperkeratosis in all neoplasms. Immunohistochemical (IHC) examination with antibodies against proliferating cell nuclear antigen (PCNA) and Ki-67 were detected in the basal layer of the epidermis and connective tissue. Bovine papillomavirus (BPV-1) antigens were detected in the basal layer. In conclusion, it was decided that the BPV-1, PCNA and Ki-67 antibodies were very useful markers in the diagnosis of bovine cutaneous papilloma.