Akademik Veri Yönetim Sistemi
İzmir Tepecik Eğitim Hastanesi Dergisi, cilt.27, sa.2, ss.131-137, 2017 (Hakemli Dergi)
Objective: We aimed to investigate the association of serum magnesium levels with the disease state in patients having necrotizing and edematous types of acute pancreatitis with or without hypocalcemia.
Methods: The hospital records of 114 patients, meeting the criteria of the revised Atlanta classification of acute pancreatitis were evaluated retrospectively for their serum magnesium, calcium, albumin and C-reactive protein (CRP) levels and leukocyte and platelet counts.
Results: Mean age of the patients was 58.9±15 years. Serum magnesium, calcium and albumin levels were significantly lower in patients with acute necrotizing pancreatitis than those of the cases with the edematous type (1.85±0.6 mg/dL vs. 2.12±0.26 mg/dL; p<0.001, 8.37±0.51 mg/dL vs. 8.86±0.59 mg/dL; p<0.001 and 3.34 g/dL±0.67 g/dL vs. 3.75±0.46 g/dL; p=0.003, respectively). Patients with hypocalcemia had lower levels of serum magnesium, and higher levels of serum CRP and leucocyte counts when compared with the patients without hypocalcemia (p<0.001, p=0.002 and p=0.002, respectively). According to the type of disease, the number of patients with advanced age increased 1.047-fold (CI: 1.006-1.089; p=0.025), normal levels of serum magnesium increased 45.4-fold (CI: 3.548-582.336; p=0.003) in patients with the edematous type, and, high levels of serum CRP increased 1.082-fold (CI: 1.017-1.157; p=0.013) in patients with the acute necrotizing pancreatitis. After the disease severity was taken under control , serum magnesium levels were found to be moderately correlated with the serum albumin levels (r=0.32; p<0.001).
Conclusion: Although patients with acute necrotizing pancreatitis and hypocalcemia revealed low levels of serum magnesium, hypomagnesemia was not associated with the disease severity in patients with acute pancreatitis.