Akademik Veri Yönetim Sistemi
7th International Cukurova Agriculture and Veterinary Congress, Adana, Türkiye, 9 - 10 Mart 2024, ss.160-162, (Özet Bildiri)
This study aimed to compare the pharmacokinetics of marbofloxacin in one-, two- and four-month old calves. The study was carried out on 18 healthy Montafon calves. The calves were divided into 3 equal groups according to their ages: one month old, two months old and four months old. Marbofloxacin was administered intravenously to all groups at a dose of 10 mg/kg. Blood samples were collected before drug administration (0 h) and at 5, 15, 30, and 45 min and 1, 2, 4, 6, 8, 10, 12, 24, 48, 72 and 96 h after marbofloxacin administration. Plasma concentrations of marbofloxacin were measured using high-performance liquid chromatography. Pharmacokinetic parameters were calculated by non-compartmental analysis. Marbofloxacin was measured from plasma until the 72, 48 and 24 h in one-, two- and four-month-old calves, respectively. The elimination half-life (t1/2ʎz), volume of distribution at steady state (Vdss), total clearance (ClT) and area under the concentration-versus time curve (AUC0-∞) values of marbofloxacin in one-month-old calves were 10.62 h, 1.03 L/kg, 0.08 L/h/kg and 127.90 h*μg/mL, respectively. It was determined that clearance increased while elimination half-life and area under the curve values decreased in parallel with the age of the calves. When one- and two-month-old calves were compared with four-month-old calves, it was determined that Vdss decreased in four-month-old calves. As a result, the pharmacokinetics of marbofloxacin changed significantly with age in calves. Since the clinical efficacy of marbofloxacin may vary depending on pharmacokinetic changes, there is a need to reveal the pharmacokinetic/pharmacodynamic relationship in calves of different ages.
Keywords: Calves, Different age, HPLC, Marbofloxacin, Pharmacokinetic.