Research Information System
8. INTERNATIONAL ANKARA MULTIDISCIPLINARY STUDIES CONGRESS, Ankara, Turkey, 16 - 18 March 2025, pp.18-19, (Summary Text)
One of the main features of cancer cells is that they tend to aerobic glycolysis at high rates and show an
increased glucose uptake pattern. In order to meet the energy and metabolic requirements of cancer cells,
there is a need for candidate molecules that can replace D-Glucose, which cancer cells prefer to use in
high amounts, and inhibit the glycolytic metabolism in these cells by different mechanisms. D-Allose is
one of the rare sugars found in small amounts in nature and is an epimer sugar from the 3rd position of
D-glucose. This rare sugar is a monosaccharide that has been found to be less toxic and ultra-low
calorific than D-glucose.
In this study, D-Allose is aimed to decrease the utilisation rate of D-Glucose in cancer cells and it was
planned to show the effect of D-Allose on the viability of MCF-7 breast cancer cells. For this purpose,
D-Allose was applied at certain concentrations to MCF-7 breast cancer cells for 48 and 72 hours in
media containing D-Glucose and cell viability was determined by MTT viability test in all groups and
IC50 values were calculated. It was observed that D-Allose exposure decreased the proliferative activity
of D-Glucose and decreased the viability of the cells depending on the concentration increase. In future
studies, it is aimed to comprehensively evaluate the metabolic effects of D-Allose molecule as an
effective anti-cancer agent candidate against breast cancer.