The protective effect of kefir on carbon tetrachloride-induced histopathological changes in the livers of rats Karbon tetraklorüre bağlı ratların karaciğerinde oluşan histopatolojik değişikliklere karşı kefirin koruyucu etkisi

Özsoy Ş. Y.

Kafkas Universitesi Veteriner Fakultesi Dergisi, vol.22, no.3, pp.403-408, 2016 (SCI-Expanded, Scopus, TRDizin) identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.9775/kvfd.2015.14825
  • Journal Name: Kafkas Universitesi Veteriner Fakultesi Dergisi
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.403-408
  • Keywords: Apoptosis, Carbon tetrachloride, Histopathology, Liver, Rat
  • Hatay Mustafa Kemal University Affiliated: Yes

Abstract

The aim of the study was to investigate the protective effects of kefir in the liver damage of rats, at experimental carbon tetrachloride (CCI4) intoxication by histologically and immunohistochemically. During the 45 days trial period, 18, female, Wistar albino rats were used. One of them was control, three experimental group was created. Twice a week 0.5 cc carbon tetrachloride (CCI4) + olive-oil (1:1) suspension was injected subcutaneously to the second and third group. At third group additionally to this administration 30 ml kefir was given daily by oral gavage. CCI4-induced hepatocellular damage and apoptosis was observed but these adverse findings reduced with kefir administration. These findings indicate that kefir may have a protective role at liver damage.