Investigating of Effects of Metformin on Melanoma Skin Cancer
Genel Tıp Dergisi, vol.31, no.2, pp.111-115, 2021 (Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 31 Issue: 2
- Publication Date: 2021
- Doi Number: 10.15321/geneltipder.2021.295
- Journal Name: Genel Tıp Dergisi
- Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.111-115
- Hatay Mustafa Kemal University Affiliated: Yes
Abstract
Aim: Apoptotic pathways are important for resistance to chemotherapeutics drugs and cancer development. Metformin is a safe, inexpensive and effective drugused to treat type 2 diabetes. Furthermore, although there is evidence of anticancer effects, the mechanisms by which metformin exerts the effects are unclear.Therefore, it was aimed to investigate Bcl-2, kaspaz-3, bax, wee-1, AIF, grp78 and gadd153 levels in metformin treated skin cancer cells. Materials and Methods: The skin cancer cells (B16F10) were treated with metformin and kaspase-3, bcl-2, wee 1, gadd153, grp78 and AIF levels were analyzedby using ELISA. Result: Treatment of metformin increased of proapoptotic proteins (kaspase-3, bcl-2, wee 1, gadd153, grp78 and AIF) and decreased antiapoptotic protein (bcl 2). Conclusion: In conclusion, this study showed that metformin has apoptotic effect on melanoma skin cancer.