Alteration of nitric oxide production in rats exposed to a prolonged, extremely low-frequency magnetic field

Akdag M. Z., Bilgin M. H., DAŞDAĞ S., TÜMER C.

Electromagnetic Biology and Medicine, cilt.26, sa.2, ss.99-106, 2007 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 2
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1080/15368370701357866
  • Dergi Adı: Electromagnetic Biology and Medicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.99-106
  • Anahtar Kelimeler: ELF magnetic fields, Nitric oxide, Rats
  • Hatay Mustafa Kemal Üniversitesi Adresli: Evet

Özet

The purpose of this study is to investigate the possible effect of an extremely low-frequency magnetic field (ELF-MF) on nitric oxide (NO) level. In this study, 27 male Sprague-Dawley rats were used. The rats were divided into three groups: two experimental and one control (sham-exposed). The first and second experimental group (n=10) were exposed to 100T and 500T ELF-MF during 10 months, 2h a day, respectively, and the third (n=7) group was treated like an experimental group except for ELF-MF exposure in methacrylate boxes. After ELF-MF and sham exposure, serum nitrite levels were measured by Griess reaction. A significant reduction was observed in nitrite levels among the first and second experimental groups of rats and sham-exposed rats after exposure for 10 months, 2h a day, to ELF-MF of 100 and 500T (p0.01). These results suggest that prolonged ELF-MF exposure at intensities of exposure limits, determined by ICNIRP for public and occupational, may reduce NO production probably affected by NO generation pathways.