Alteration of nitric oxide production in rats exposed to a prolonged, extremely low-frequency magnetic field
Electromagnetic Biology and Medicine, vol.26, no.2, pp.99-106, 2007 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 26 Issue: 2
- Publication Date: 2007
- Doi Number: 10.1080/15368370701357866
- Journal Name: Electromagnetic Biology and Medicine
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.99-106
- Keywords: ELF magnetic fields, Nitric oxide, Rats
- Hatay Mustafa Kemal University Affiliated: Yes
Abstract
The purpose of this study is to investigate the possible effect of an extremely low-frequency magnetic field (ELF-MF) on nitric oxide (NO) level. In this study, 27 male Sprague-Dawley rats were used. The rats were divided into three groups: two experimental and one control (sham-exposed). The first and second experimental group (n=10) were exposed to 100T and 500T ELF-MF during 10 months, 2h a day, respectively, and the third (n=7) group was treated like an experimental group except for ELF-MF exposure in methacrylate boxes. After ELF-MF and sham exposure, serum nitrite levels were measured by Griess reaction. A significant reduction was observed in nitrite levels among the first and second experimental groups of rats and sham-exposed rats after exposure for 10 months, 2h a day, to ELF-MF of 100 and 500T (p0.01). These results suggest that prolonged ELF-MF exposure at intensities of exposure limits, determined by ICNIRP for public and occupational, may reduce NO production probably affected by NO generation pathways.