Akademik Veri Yönetim Sistemi
Bayraktar H. S. (Yürütücü)
Doktora Sonrası Araştırma Programı Projesi, 2021 - 2023
Abstract Aim The aim of this study was to evaluate the effects of oleuropein oral intake on infected fat grafts and fat graft survival. the antibiotics of chemical synthesis. P. aeruginosa and S. aureus surgical site infections could treat and prevent safely and effectively by oleuropein, particularly in early and late periods after surgery. Materials and Methods 32 Wistar albino rats were divided into four groups: 0. none treated, 1. serum oral intake, 2. antibiotic oral intake, and 3. oleuropein oral intake. The dorsal regions of the rats were separated into four quad rants as right and left cranial, and right and left caudal to determine each quadrant where fat grafts were placed. Right cranial and caudal quadrants were infected with the methicillin-susceptible Staphylococcus aureus (MSSA) strain. The left cranial and caudal quadrants were infected with the Pseudomonas aeruginosa strain. On the 7th day and end of the 3rd month, fibroblast density, inflammation, and fat survival were demonstrated immunohistochemi cally with FGF, CD68, and perilipin (PP), respectively. Results On the 7th day, for P. aureginosa-infected grafts, oleuropein was shown higher rates in CD68 and PP stain ing compared to the antibiotic group (p\0.05, p\0.001, respectively). At the end of the 3rd month, for P. auregi nosa and S. aureus-infected grafts, the oleuropein group was demonstrated improved PP staining rates compared to the antibiotic group (p\0.01, p\0.01, respectively). Conclusion Oleuropein as a natural olive leaf extract with potent antioxidant, anti-inflammatory, and antimicrobial features is an alternative and supportive agent for both treatment and prophylaxis of surgical site infections like