Akademik Veri Yönetim Sistemi
Bayraktar H. S. (Yürütücü)
Diğer Resmi Kurumlarca Desteklenen Proje, 2024 - 2025
Introduction:
Extended-Spectrum
β-Lactamase (ESBL)-producing Escherichia coli (E. coli) and
Klebsiella pneumoniae (K. pneumoniae) are threatening pathogens
which are more resistant to antibiotics in healthcare settings all around the
world. The spread of these pathogens may be triggered by natural disasters such
as earthquake and flood.
Material
and method: A total of 3129 subjects were included in
this study and evaluated retrospectively between January 2023 and July 2024 just
before and after a major earthquake. VITEK 2 compact automatized system was used
to identify the strains and ESBL production and antibiotic resistance of
isolates were determined by conventional methods.
Results:
Nine
hundred and fifty two E. coli and 355 K. pneumoniae strains were isolated
from 3129 clinical samples. The 478 E. coli (50.21%) and 102 K.
pneumoniae strains (28.73%) were found to be ESBL positive. ESBL-producing E.
coli strains were mostly resistant to cefuroxime (97.48%), ceftriaxone
(84.51%) and 97.05% resistance rate was determined in ESBL positive K.
pneumoniae strains against ceftriaxone. ESBL-producing K. pneumoniae strains
were completely resistant to cefuroxime.
Conclusion:
Although
ESBL positivity was high in E. coli strains, but not significantly
different when compared with literature, it was found to be relatively moderate
in K. pneumoniae strains. It can be said that despite the major
earthquake disaster, these findings are promising. For
sustainability of infection control, approaches should be taken to improve the
environmental sanitation/hygiene precautions and antibiotic treatment protocols
in both environment and each healthcare facilities even in negative situation.